San Francisco 49ers 2025 Opponents. The san francisco 49ers remain one of the top super bowl contenders heading into 2025. San francisco will have its regular nfc west games, but they’ll also face the afc east, nfc north, and winners from the nfc east, nfc south and afc west.
View the 2025 san francisco 49ers schedule at fbschedules.com. Here are the home and away opponents for san fran in the 2025 nfl regular season.